Department of Computer Science
 Rutgers University

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ArrayCGH: Analyzing comparative genomic hybridization data

Detecting Chromosomal aberrations from ArrayCGH and gene expression ArrayCGH experimental data Chromosomal aberrations such as deletions or duplications of chromosomal regions are a crucial contributing factor to cancer. The aberrations can be detected by observing the relative hybridization intensities of healthy vs. diseased patients for BAC-clones covering complete genomes. A Hidden Markov Model with a inhomogeneous Markov Chain allows to reflect dependencies between overlapping clones.

Contact: Alexander Schliep (schliep@cs.rutgers.edu).